As cyber threats continue to grow in sophistication, businesses are looking for comprehensive security solutions to protect their digital environments. One such solution is Microsoft Defender for Endpoint, a powerful tool that safeguards endpoints (like laptops, desktops, and mobile devices) from various cybersecurity risks. When paired with Intune, a unified endpoint management solution, Microsoft Defender for Endpoint becomes even more powerful, offering businesses a seamless approach to security and device management. In this article, we’ll explore what is Microsoft Defender for Endpoint, how to configure Microsoft Defender for Endpoint in Intune, and the combined benefits of using Intune Microsoft Defender for Endpoint for your business.
What is Microsoft Defender for Endpoint?
Microsoft Defender for Endpoint is a comprehensive, enterprise-grade endpoint protection platform designed to protect against a wide range of cyber threats. It provides advanced threat detection, automated response to incidents, and detailed reporting on the security posture of your devices. This service is part of the broader Microsoft Defender suite, offering protection across various Microsoft services and devices.
At its core, Microsoft Defender for Endpoint offers a variety of features:
- Real-time protection from malware, ransomware, and other attacks.
- Endpoint detection and response (EDR), which helps monitor and respond to threats.
- Automated investigation and remediation of security incidents.
- Threat and vulnerability management to help identify and fix potential security risks.
- Attack surface reduction measures that prevent attacks before they happen.
The ultimate goal of Microsoft Defender for Endpoint is to safeguard the endpoints of an organization, such as computers, mobile devices, and servers, from the increasing number of cyber threats in today’s fast-paced digital world.
Why Integrate Microsoft Defender for Endpoint with Intune?
Microsoft Intune is a cloud-based endpoint management service that allows businesses to manage and secure their devices, apps, and data from one central platform. When you combine Intune Microsoft Defender for Endpoint, the integration allows organizations to enforce security policies, monitor devices in real-time, and respond to potential threats from a single, unified interface. This powerful combination gives IT administrators a streamlined process for protecting their company’s devices, reducing complexity, and improving response times to potential security incidents.
By integrating Microsoft Defender for Endpoint with Intune, businesses can:
- Simplify device management: You can enroll and manage all devices from one place, whether they’re Windows, macOS, iOS, or Android.
- Ensure consistent security: Automatically deploy security policies, updates, and patches across all devices.
- Enhance compliance: Leverage Microsoft Defender for Endpoint’s built-in compliance features to meet industry-specific regulations like HIPAA, GDPR, and more.
When Microsoft Defender for Endpoint is used in conjunction with Intune, businesses get the added benefit of device configuration, security, and monitoring through a single dashboard, enabling proactive security management with minimal administrative overhead.

How to Configure Microsoft Defender for Endpoint in Intune
Configuring Microsoft Defender for Endpoint in Intune can seem complex, but with a few simple steps, businesses can ensure that all their devices are adequately protected and managed. Here’s how you can do it:
Step 1: Prerequisites for Integration
Before configuring Microsoft Defender for Endpoint in Intune, make sure you have the following:
- A Microsoft 365 tenant.
- The appropriate Microsoft Defender for Endpoint and Intune licenses for your organization.
- The necessary permissions to configure security settings in both Defender for Endpoint and Intune.
Step 2: Set Up Microsoft Defender for Endpoint
- Activate Microsoft Defender for Endpoint in the Microsoft 365 security center by following the prompts to set up the security policies.
- Go to the Microsoft Defender Security Center and configure your organization’s device security settings. This will include setting up attack surface reduction rules, antivirus, and EDR settings.
- Once set up, Microsoft Defender for Endpoint will start collecting security data from your devices.
Step 3: Configure Microsoft Defender for Endpoint in Intune
- Go to the Microsoft Endpoint Manager admin center and sign in with your admin credentials.
- In the Endpoint security section, click on Microsoft Defender Security Settings. This will guide you to configure and manage security policies for all enrolled devices.
- Create a Security Policy Profile that integrates Microsoft Defender for Endpoint into Intune. This allows you to set rules for things like attack surface reduction, firewall configurations, antivirus protection, and more.
- Assign the policy to devices. Intune allows you to assign the policy to specific groups, including all devices or only certain categories (like mobile devices, PCs, etc.).
Step 4: Monitor and Adjust Policies
After the configuration is complete, you can use Intune to monitor devices in real-time. You’ll have access to alerts, device status reports, and the security health of each endpoint. You can also adjust policies based on the latest threats or security insights provided by Microsoft Defender for Endpoint.
With Intune Microsoft Defender for Endpoint, ongoing management and fine-tuning are made easy, allowing you to ensure that devices remain secure while minimizing administrative work.

Benefits of Using Intune Microsoft Defender for Endpoint
1. Streamlined Security Management
By integrating Microsoft Defender for Endpoint with Intune, businesses can manage security across all devices from a central platform. IT admins no longer need to toggle between different consoles for endpoint protection and device management, saving time and resources.
2. Unified Device Protection
With Intune Microsoft Defender for Endpoint, businesses gain real-time, continuous protection for all their devices—whether on-premises or remote. The integration automatically applies security configurations, patches, and updates to devices, ensuring that all endpoints are protected without manual intervention.
3. Improved Incident Response
If a security incident occurs, the integration between Microsoft Defender for Endpoint and Intune enables faster response times. IT admins can receive alerts, isolate compromised devices, and begin remediation steps quickly. This centralized approach ensures that any security breach is contained as soon as possible, minimizing potential damage.
4. Scalable Security for Growing Organizations
As companies expand, so do their IT infrastructures. The integration of Intune Microsoft Defender for Endpoint ensures that security measures scale along with the business. Whether you’re adding new employees, devices, or locations, the solution allows seamless scalability without adding complexity to the management process.
5. Enhanced Compliance and Reporting
For businesses that need to comply with regulatory standards such as HIPAA, GDPR, or PCI DSS, Microsoft Defender for Endpoint in Intune provides the necessary tools for enforcement. The system tracks and generates security reports that help demonstrate compliance during audits, giving companies peace of mind.
6. Reduced Administrative Overhead
The combination of Intune and Microsoft Defender for Endpoint reduces the burden on IT teams by automating much of the security management process. This helps IT staff focus on higher-value tasks, such as strategic planning and innovation, rather than spending time on routine security tasks.
Conclusion
In 2025, endpoint security is more critical than ever, and businesses need to adapt to the increasingly complex cybersecurity landscape. Microsoft Defender for Endpoint, when configured with Intune, offers a comprehensive solution that not only protects devices but also streamlines security management across your organization. By integrating these two powerful tools, businesses can ensure robust protection, compliance, and ease of use, all while saving time and resources.
If you haven’t yet considered Intune Microsoft Defender for Endpoint, now is the time to do so. Whether you’re looking to secure your devices, streamline security management, or improve your organization’s response to cyber threats, the combination of Intune and Microsoft Defender for Endpoint is the way forward.



